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AGING THERAPEUTICS


Senescent cell removal, insulin signaling inhibition/caloric restriction, and rapamycin (mTOR inhibition) extend lifespan in mice the most in our meta-analysis of over 100 different aging interventions. Surprisingly, the natural molecule fisetin simultaneously address all three, offering great promise as a therapeutic.

References:
[1] Yousefzadeh MJ, Zhu Y, Mcgowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28.
[2] Adhami VM, Syed DN, Khan N, Mukhtar H. Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem Pharmacol. 2012;84(10):1277-81.

NANOPARTICLES


Transmission Electron Microscopy of 10 nm MNPs



Magnetic nanoparticles (MNPs) can serve as a vehicle after coating to conduct targeted delivery of dissolved fisetin to improve bioavailability.

Thermal Release Nanoparticles

Polymer Coated Nanoparticles

Porous Nanoparticles

Fisetin has low bioavailability and is quickly cleared from the body, limiting its effectiveness. Due to its excellent safety profile, clinical trials using large doses of fisetin are currently underway in hopes it can help in human aging despite these drawbacks. At ETTA, we are trying a different way. Our proprietary metal core nanoparticles can deliver fisetin, as well as other small molecules, RNA, DNA, and proteins, to treat a wide range of diseases.