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NANOPARTICLE TARGETING

Nanoparticles to deliver mRNA and DNA will revolutionize treatments targeting aging. However, they can only be delivered to a handful of cell types. We are developing nanoparticles that can target all 200 cell types in the human body.

FISETIN


Senescent cell removal, insulin signaling inhibition/caloric restriction, and rapamycin (mTOR inhibition) extend lifespan in mice the most in our meta-analysis of over 100 different aging interventions. Surprisingly, the natural molecule fisetin simultaneously address all three, offering great promise as a therapeutic.

References:
[1] Yousefzadeh MJ, Zhu Y, Mcgowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28.
[2] Adhami VM, Syed DN, Khan N, Mukhtar H. Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem Pharmacol. 2012;84(10):1277-81.